(1148-A) Development of a sticker sealed microfluidic device for in situ analytical measurements using synchrotron radiation

Abstract: Shining synchrotron light on microfluidic systems, our study delves into in situ and operando investigations at the nanoscale. Techniques such as X-ray fluorescence, diffraction, luminescence, and absorption reveal novel material properties in fields like green energy, photonics, and nanomedicine.
In this work, we present a versatile polyester/glass microfluidic device designed for seamless integration with analytical X-ray methods. The device features microchannels etched into glass, accommodating three gold electrodes for in situ electrochemical analysis or standard electrical measurements. It boasts efficient sealing through a UV-sensitive, sticker-like polyester film.
Our device exhibits impressive chemical resistance to organic solvents and excels in the presence of biological samples, including proteins. Its high transparency to X-rays was validated by 2D X-ray nanofluorescence mapping, conducted at the X-ray nanoprobe Carnaúba/Sirius/LNLS.
In conclusion, our microfluidic device, as characterized in this study, holds the potential for widespread applications, from standard laboratory experiments to in situ and in vivo analytical investigations across the electromagnetic spectrum, spanning from infrared to X-rays, enriching various scientific disciplines.