(1405-B) Multiplex analysis of Predictive Oncology’s 3D tumor models using Tecan’s Spark® Cyto imaging multimode reader

Abstract: Bringing the human element into early drug discovery can help to greatly bolster success during clinical trials. Predictive Oncology’s multi-component, organ-specific extracellular matrix (ECM) incorporates human tissue architecture to enable a more in vivo representative method of testing drug candidates. This allows more accurate predictions of a tumor’s response to drugs, optimization of candidate screening, and enhanced evaluation of off-target toxicity and biomarker discovery.
Analyzing these valuable 3D tumor models requires a powerful instrument capable of performing multiplexed analysis in a live cell environment. Tecan’s Spark Cyto combines standard microplate detection modalities with brightfield and fluorescence imaging technologies and incorporates environmental control features that create a healthy environment for living cells, as well as unique integrated lid-lifting capabilities.
This poster summarizes the results of four independent studies that highlight the potential of the Spark Cyto reader as a valuable tool in the analysis of cells cultivated in 3D cultures, namely the r-Breast, r-Tube, r-Pancreas and r-Liver models.

Spark Cyto is for Research Use Only. Not for use in diagnostic procedures.