Over the last 20 years, the constant push for Compound Management organizations to deliver larger quantities, faster and cheaper, while maintaining high quality and prolonging the life of the collection has forced creative, out of the box, innovation resulting in four major transformations. The iron triangle, as it has been referred to, also applies to driving innovation for compound management, since the speed and the quality at which compounds can be delivered in a usable form for screening directly impacts the decision-making process for projects in drug discovery and our ability to implement new, innovative technology is often directly driven by cost. The necessity to constantly reduce cycle times and reduce the costs of early drug discovery has driven evolutionary advances in compound management hardware and software, which drive every workflow. In the early 2000’s, prior to the wide usage of fully automated processing, sample management operations were mainly manual, siloed processes delivering screening sets as needed from NEAT samples. Over time, larger screening campaigns with faster turnaround requirements have driven innovation towards centralized, large, fully automated, sample stores utilizing 384-well storage standards such as the REMP tube racks to deliver near assay-ready-plates (nARP). During that time, the need for compound management to deliver assay-ready plates (ARP) to reduce the downstream sample logistics burden eventually forced the need for cutting-edge acoustic droplet ejection to deliver low-volume ARP in high density formats including 1536. Today, the utilization of the latest acoustic plating platforms coupled with fully automated acoustic tube stores for large compound libraries has become commonplace in compound management facilities to decouple production bottlenecks and fulfill an even wider variety of screening and follow-up requests in a greater array of nARP and ARP formats, which are now created in half the time. These latest innovative solutions utilize state of the art integrated hardware and software from Azenta, Beckman, Highres Biosolutions, and Scigilian and require a skilled and highly experienced team of internal automation and data specialists who have endured the years of innovation and development to enable the implementation of these transformational advances in systems for compound management.