Erin and Erin began This Podcast Will Kill You in 2017, the last year of their PhDs, for two primary reasons: first, because they had begun to feel an increasing disconnect between academic research and the general public and wanted to try to bridge that gap, and second, because they just loved talking about diseases. Each episode of This Podcast Will Kill You explores a disease or other medical topic from biological, historical, and epidemiological perspectives and uses scientific storytelling to build connections with the audience, humanizing what can often be a very impersonal field. Their conversational approach serves to engage and entertain listeners while providing a low-pressure learning environment, and their willingness to engage with uncertainty when explaining complex topics helps to build and maintain trust with their audience. Over the last six years and over 150 episodes, This Podcast Will Kill You has reached millions of listeners around the world, scientists and non-scientists alike, and has worked towards demystifying how science is done to increase trust and understanding with the general public. In this keynote, Erin and Erin share some of their lessons in science communication, including the importance of striking a balance between clarity and depth, how to tailor your explanation for a specific audience, and why admitting what you don’t know is an undervalued strength.