Dr. Catherine Klapperich is Professor of Biomedical Engineering at Boston University. She holds appointments in the Department of Mechanical Engineering and in the Division of Materials Science and Engineering. She is the Scientific Director of the Design, Automation, Manufacturing, and Process Laboratory (DAMP Lab) in the BU Biological Design Center. In 2020, Dr. Klapperich led the design and scale up of campus wide COVID-19 testing in a new facility on the Charles River Campus. Dr. Klapperich’s leadership brought together expertise in assay development, liquid handling, software design and development, data analytics and security, regulatory issues, and clinical test provision. Between July 2020 to May 2022, the lab performed about 2.5 million COVID-19 PCR tests. In this talk, Dr. Klapperich will discuss the challenges and successes of this quick automation scale up. She will summarize both engineering and clinical lessons learned from this undertaking and will end with a discussion of the next steps as the DAMP lab transitions to a paper free cloud-based biofoundry.