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Sarine Markossian, PhD (she/her/hers)

NCATS/NIH, Maryland, United States

Dr. Sarine Markossian is the lead of the Assay Guidance Manual (AGM) Translational Science Resources Program at the National Center for Advancing Translational Sciences (NCATS). This program is a unique translational science initiative that aims to create and disseminate best laboratory practices, tools for data analysis, and standards for rigor in preclinical drug discovery. In this role, Markossian serves as the editor-in-chief of the AGM eBook — a free, best-practices online resource devoted to the successful development of robust, early-stage drug discovery assays — and manages the program’s training workshops. Markossian also manages research projects focused on eliminating bottlenecks in preclinical translational science by improving assay robustness and reproducibility, addressing assay artifacts and interferences, and establishing best practices for preclinical research. She also serves as an editorial board member of SLAS Discovery.

Prior to joining NCATS in 2020, Markossian was a senior scientist in the Department of Pharmaceutical Chemistry at the University of California, San Francisco (UCSF) in the laboratory of Dr. Michelle R. Arkin. At UCSF, she co-led the Drug-Induced Liver Injury (DILI) team, as part of the Accelerating Therapeutics for Opportunities in Medicine consortium, which developed and profiled compounds across multiple assays, including multiparametric high-content assays, to measure hepatocyte cell health and to build in silico models to predict DILI. Markossian earned her doctorate in molecular genetics from The Ohio State University and completed her postdoctoral training at the National Institute of Child Health and Human Development.

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