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Sharon Tentarelli (she/her/hers)

AstraZeneca, Massachusetts, United States

Sharon Tentarelli is an Associate Principal Scientist at AstraZeneca in Oncology R&D Chemistry and has 30 years’ experience working in analytical chemistry. At the Massachusetts Institute of Technology her undergraduate research focused on polymer synthesis and characterization. After receiving a BS degree in 1993, she began her career at Polaroid in an analytical department that supported both R&D process development and manufacturing production. Her work included converting legacy methodology to newer chromatographic and mass spectrometry based techniques. In 2001, she began working at AstraZeneca in early-stage drug discovery, supporting both Oncology and Infection therapy areas. Over the years her mass spectrometry work has ranged from routine analyses around purity confirmation and structural elucidation, to customization and repair of open-access LC-MS instrumentation, to development of more bespoke assays. She has established biomarker analyses supporting pre-clinical efficacy and safety studies, hydrolytic screening cascades supporting formulation, and intracellular drug concentration studies addressing compound uptake in biological assays. She has also written script-based automation to streamline routine analytical workflows. She has co-authored 16 manuscripts in peer-reviewed journals including Nature Communications and SLAS Technology.

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