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Clarence Yapp, PhD

Harvard Medical School, Massachusetts, United States

Dr. Clarence Yapp (DPhil) is the Director of Microscopy and Computer Vision at the Laboratory of Systems Pharmacology at Harvard Medical School. His background is in developing microscopy-based tools for studying diseases. Since 2007, he has been designing experiments over a wide variety of imaging methods including whole slide imaging, high-content microscopy, 3D confocal and two-photon imaging. His primary interests are developing state-of-the-art methods to enable users to correctly acquire and analyze their image data. After his PhD, which was supervised by Professor Udo Oppermann, he developed an interest in applying microscopy and image analysis for high content screening of chemical probes against novel epigenetic targets during his postdoctoral studies under Dr. Susanne Muller-Knapp at the Target Discovery Institute, Oxford, UK. During this time, he was invited to manage the microscopy facility at the Botnar Research Center in Oxford, UK. He extended his career to Harvard Medical School (HMS) in 2016 where he continues to ensure that users receive adequate guidance on the acquisition and analysis of their data as a Platform Director at the Laboratory of Systems Pharmacology (LSP) and, previously, as a research associate at the Image and Data Analysis Core (IDAC) to serve the entire network of HMS and the nearby 3 research hospitals. He is one of the co-developers of the widely successful opensource image analysis pipeline called MCMICRO. Over the past 3 years, he was co-chair of the HTAN (Human Tumor Atlas Network) Imaging subworking and Molecular Characterization Working Groups – a National Cancer Institute initiative. Here, he co-organized various workshops/hackathons and initiatives that assessed quality of different image modalities, visualized highly multiplexed datasets, and curated metadata from microscopy datasets. More recently, he was part of the Institute of Chemistry and Cell Biology (ICCB-L) where he advised in an assay design role.

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