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University of California, Santa Cruz, California, United States
Dr. John MacMillan is the Vice Chancellor for Research and Professor in the Department of Chemistry and Biochemistry at the University of California at Santa Cruz, where his laboratory focuses on the discovery and characterization of biologically active molecules from microorganisms. This research has focused on the therapeutic areas of infectious disease and oncology, combining phenotypic screening, isolation and mechanism of action studies towards the discovery of natural products. His collaborative work in the area of oncology led to proof of concept molecules for targeting HIF-2 for treatment of VHL syndrome. The labs work in the area of natural products mechanism of action has yield multiple approaches, such as FUSION, to look at the mechanisms on a library scale. This work has led to establishment of the Center for High Functional Annotation of Natural Products, a multi-institutional center funded by the NIH to study the mechanism of natural products.
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Phenotypic Screening in Natural Products Discovery
Wednesday, February 7, 2024
1:00 PM – 1:30 PM EST