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Michael Ronzetti (he/him/his)

NIH/NCATS, District of Columbia, United States

Michael Ronzetti is a predoctoral Intramural Research Training Award fellow refining his expertise in chemical biology at the National Center for Advancing Translational Sciences (NCATS). Holding a B.S. in Neuroscience from the University of Michigan, Michael is poised to complete his doctoral studies this summer at the University of Maryland as a Graduate Partnership Program (GPP) fellow with the National Institutes of Health (NIH). Leveraging his proficiency in assay design and platform development, he spearheads multiple projects at NCATS, focusing on the creation of diverse assays—cell-based, biochemical, and biophysical—to investigate therapeutic targets for rare diseases and critical public health challenges.

His contributions to early-stage drug discovery have significantly advanced the field, particularly through the development of novel assays and methodologies, such as the real-time cellular thermal shift assay for monitoring protein-ligand interactions, and high-yield protein production techniques for therapeutic targets, leading to the discovery of highly potent small molecule inhibitors. Additionally, his interdisciplinary research has provided deep insights into tumor-associated macrophages, enhancing understanding of cancer immunotherapy, and contributed to the understanding of host-parasite interactions in microbiology, particularly in Lyme disease, offering new targets for therapeutic intervention.

Disclosure information not submitted.

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