(1084-A) Nuclear Magnetic Resonance-Based Metabolomics Study of Human Embryonic Kidney (HEK 293T) Cells Cultured on Self Assembled Monolayer-Coated Indium Tin Oxide (ITO).
Monday, February 5, 2024
12:00 PM – 1:00 PM EST
Location: Exhibit Halls AB
Abstract: Kidney disease is a leading cause of death in the United States. Animal models were mainly used to study drug metabolism, and kidney disease progression. However, most of these models have led to a failure of drug design in renal applications caused by the differences between the human body and the animal models used for its development, thus leading to incorrect predictions. Also, the need for clinical translation of these preclinical models used to evaluate the efficacy or toxicity of drugs is one of the critical causes of the high failure rates. The use of the human kidney cell line Hek293T for renal studies is encouraged because of its ability to give accurate predictions. Given the relevance of this cell line, it is, necessary to study its metabolomics. This study provides the 1D and 2D NMR spectroscopy analysis of HEK293T cells cultured on ITO-MPS substrate. The ITO-MPS substrate was characterized using FTIR, XPS, SEM, and Contact Angle Measurement. The proliferation of the cells was measured using the MTT Assay.