(1226-C) Automated production of human neuromuscular organoids using a customized robotic system.
Tuesday, February 6, 2024
12:00 PM – 1:00 PM EST
Location: Exhibit Halls AB
Abstract:
Background: Human neuromuscular organoids offer unprecedented opportunities for studying muscle-nerve interactions, disease modeling, and drug screening. However, the conventional manual production of organoids is labor-intensive, time-consuming, and prone to variability.
Objective: To overcome these challenges, our study aims to automate the production of human neuromuscular organoids, with a focus on enhancing efficiency, reproducibility, and cost-effectiveness.
Methods: We employed a state-of-the-art customized liquid handling robotic system, which precisely recapitulates cell culture conditions to facilitate the production of organoids on a large scale. The system was programmed to replicate the intricate steps required for neuromuscular organoid generation.
Results: The automated process significantly reduced human intervention, improving the reproducibility of organoid characteristics. Comparative analyses revealed the morphological and functional similarities between organoids generated by the automated system and the manually produced counterparts. Notably, the automated production improved the consistency in size.
Conclusion: Automated generation of human neuromuscular organoids using liquid handling robotics marks a significant advancement in regenerative medicine research. This technology paves the way for high-throughput organoid production, promising to accelerate disease modeling and drug discovery.