Assay Development and Screening

(1000-A) A High-Throughput Compatible Live-Virus Human Spheroid-Based Screening Platform to Identify Antiviral Compounds Against Viruses with Pandemic Potential

(1001-B) A comprehensive influenza reporter virus panel for high-throughput deep profiling of neutralizing antibodies

(1002-C) A Next-Generation, Cloud-based Viral Infectivity Assay for Rapid, High-Throughput Screening of Vaccines and Antivirals

(1003-D) Characterization and comparison of hypoxia inducing factors on tumor growth and metastasis in 2D and 3D tumor models

(1005-B) A Novel Quantitative High Throughput Screening (qHTS) Assay for Human Neurotoxicity Using 3D-suspension Culture of Dopaminergic Neurons

(1006-C) A Rapid Method for Simultaneously Determining an Optimal Buffer and the LLOQ of a Small Molecule, a Peptide and a Protein Using a Liquid Handler and an Acoustic Ejection-Enabled QTOF Mass Spectrometer

(1007-D) A Rapid, High-Throughput and Effective Process for Identifying Molecular Glues Using Affinity Selection Mass Spectrometry (ASMS)

(1008-A) A non-faradaic, point-of-care, multiplex, electrochemical wound healing biosensor for profiling of regenerative biomarkers

(1009-B) A Real-Time Cellular Thermal Shift Assay to Monitor Target Engagement

(1147-D) A validated Method For the Quantification of Protacs – 3 – Gefitibib in Rat Plasma to Support Rodent PK Studies

(1014-C) Automated and high-throughput T-cell immunophenotyping assays using Celigo and Cellaca PLX image cytometers

(1015-D) Alternative cell counting and viability detection using NexGreen/PI fluorescent stain on multiple low- and high-throughput image cytometry platforms

(1019-D) Automated technique to examine the cell viability of 3D cancer spheroids using the the OT-2

(1021-B) AutoHCS: AI-based scoring of high-content screens results in morphological clustering that predicts mechanisms of action.

(1025-B) Automating selection of engineered target cell lines for Chimeric Antigen Receptor T cells

(1026-C) Cross-platform assessment of high-throughput mass-spectrometry based quality control of compound libraries

(1027-D) Developing a multiplex assay to monitor apoptosis and necrosis using the Cellaca® PLX Image Cytometer

(1033-B) Extracellular ATP measurement in real time using live cells

(1041-B) Engineered human neuromuscular junction- on-a-chip platform as a drug development tool supporting development of therapies

(1042-C) High throughput end-to-end automation of Pan Cancer HuID workflow provides high quality, consistent results from plasma samples with various cancer mutations

(1043-D) High-throughput 3D spheroid co-culturing platform for screening of organ-organ interactions

(1048-A) Development of a MALDI-TOF MS high-throughput capable screening assay for iPSC macrophage phenotyping and drug compound characterization

(1052-A) Electric field-Assisted Automatable Dried Blood Spots Sample Preparation device for Neonatal Abstinence Syndrome Screening

(1054-C) Multiplexed Cardiomyopathy and Proarrhythmia (Cardiotoxicity) KIC Assay of Human iPSC-Cardiomyocytes

(1055-D) • nELISA High-Throughput Protein Profiling of Adipocytes Provides Mechanistic Insights into Immunometabolism

(1056-A) Live Cell Painting: Drug Responses in Human Primary Patient Cells with a New Nontoxic Dye

(1057-B) In vitro cytotoxicity and genotoxicity of chalk dust particles generated in South African class rooms

(1059-D) ReFRAME: Empowering Drug Repurposing Through an Open-Access Library of 12,500 Compounds for Broad-Spectrum High-Throughput Screening

(1062-C) Pooled image-based phenotypic compound screening in human cells enabled by Ghost Cytometry with DNA barcoding technology

(1063-D) The power of high-throughput high, content screening in condensate-based drug discovery

(1064-A) High-throughput characterization of isozyme-specific Aldehyde Dehydrogenase (ALDH) inhibitors

(1065-B) Plate-based screening approaches and mechanistic insights to inform optimization of PROTAC® degraders for the treatment of neurodegenerative disease

(1066-C) Targeted LC-MS with Automated Sample Preparation Enables High-Throughput Screening Assessment of the Conjugatability of SMARTag® Peptides

(1068-A) Identification of small molecules targeting FoxP3 by high-throughput drug screening: search for specific regulators

(1069-B) SARS2 Entry Helix Bundle HTS Campaign

(1070-C) Development of a high-throughput image cytometric screening method as a research tool for immunophenotypic characterization of patient samples from clinical studies

(1071-D) High-throughput SARS-CoV-2 antiviral testing method using Plate-Based Image Cytometer

(1072-A) Increasing protein extraction throughput for cell-based assays; integration of an AFA-assisted ultrasonication and an automated liquid handling workstation to study biological perturbations

(1073-B) Measuring apoptotic effects of EP4A1 and EP4A2 on Kuramochi with a high-throughput multiplex image cytometric method

(1074-C) 3D Brain Perfusable Vascularized Model to Study Neurotropic Flavivirus Recombinant NS1 Induced Endothelial Dysfunction

(1078-C) A novel cell-based assay to identify the FLT3 kinase construct used in enzyme inhibition assays that best represents the activity of cellular FLT3

(1081-B) High-throughput, AI-driven, pooled phenotypic CRISPR screening by ghost cytometry.

(1086-C) Revolutionizing Renal Research: Microfluidic Kidney Tubuloids-on-a-Chip for Improved Drug Translation

(1087-D) Vascular inflammation modulates Trans-Endothelial Electrical Resistance and immune cell migration in a scalable organ-on-a-chip platform

(1091-D) A Novel Sox-based Continuous and Homogeneous Assay for the Discovery of Inhibitors of Inactive and Active AKT

(1093-B) A Proven Activity-Based Workflow for the Identification and Characterization of Time-Dependent Kinase Inhibitors Using a Continuous Assay Format

(1094-C) A solution for reducing carryover signal and improving throughput of fluorescence fragment analysis on microfluidic electrophoresis platform

(1095-D) Applying the right reference standard for high throughput ssDNA size analysis

(1098-C) Citron kinase: the tasty juice of the early drug discovery

(1099-D) Development and validation of a HTS Platform for the discovery of new antifungal agents against fungal plant pathogens

(1101-B) Development of Cell-based Assays for the Identification and Characterization of Inhibitors of Mutant G323E Hypoxia Inducible Factor-2α (HIF-2α).

(1102-C) High Content Imaging Is Now High Throughput: End-to-End High Content Imaging and Subcellular Analysis of Autophagy in Minutes

(1103-D) High Content Phenotypic Screening of Cell Paint Assays on Araceli Endeavor®

(1104-A) The ultra-HTS cell lysate-based platform to discover small molecule modulators of p38/MK2 protein-protein interaction for therapeutic discovery

(1105-B) IMMUNATURAL: An HTS Platform for the discovery of small-molecules from microbial origin against the PD-1/PD-L1 protein-protein interaction.

(1107-D) The Development of a Novel Mobility Shift Analysis System for Kinase Small Molecule Drug Discovery using the SCIEX BioPhase 8800

(1122-C) Production of peroxynitrite by cancer-associated immune cells can be detected with a fluorescence-based assay

(1128-A) Active-site and allosteric cyclic peptide inhibitors of secreted M. Tuberculosis Chorismate Mutase

(1132-A) Assessing microenvironment recapitulation of a 3D printed ovarian-tumoroid-on-a-chip via PARP inhibitor treatment response

(1138-C) Quantitative Analysis of Protein Translocation using High-Content Imaging and YT-SOFTWARE

(1192-A) AlphaLISA SureFire® Ultra™ technology as a unique platform to demonstrate TREM2/DAP12 signalling cascade activation in the neuroinflammatory disease space

(1139-D) The power of combining PROTAC degraders targeting cyclin-dependent kinases (CDK4/CDK6) with AlphaLISA® SureFire® screening technology for the study of cell cycle regulation in oncology

(1141-B) Developing a High-throughput Screening Assay for Myelination and Demyelination Promoting Compounds using Human iPSC-derived Schwann cell progenitor cells, Motor Neurons and Sensory Neurons from the Same Donor

(1142-C) CRISPR knockout screening for drug target identification and validation using CRISPR-Ready ioMicroglia

(1144-A) Development of a high-throughput compatible, neuronal spheroid ALS disease model

(1149-B) A NanoBRET™ Target Engagement Assay for Querying Domain Selectivity at Full-Length Polymerase Theta in Live Cells

(1150-C) PROTAC and Molecular Glue Mediated Degradation of Neosubstrates using HiBiT-tagged Cell Lines in a High-Throughput Screening Workflow

(1152-A) Development of novel 9H-carbazole-4H-chromene molecular hybrids as multi-target directed ligands for the treatment of Alzheimer’s disease

(1153-B) Discovery and Development of Small Molecules by Information-rich Next Generation Multiplexing SPR

(1154-C) Throughput Meets Flexibility: The Next Generation Multiplexing SPR for Efficient Therapeutic Protein Discovery and Development

(1156-A) Electric-field Assisted Sample Preparation of Whole Blood and Dried Blood Spots for Steroid Quantification using LC-MS/MS

(1157-B) Practical Evaluation of Time-Dependent Inhibition Kinetics Through Small-Volume Size-Exclusion Chromatography

(1158-C) Live Cell Painting: enhancing throughput and insights in drug discovery with a novel non-toxic, mix-and-read method for high-content screening

(1161-B) Fast Kinetic Imaging and Analysis of Intracellular Dynamics in Human iPSC- derived Neurons

(1166-C) Advanced 3D Cell Models for Next Generation Therapeutics: Standardized Organoid Co-Cultures and Assays in Microwell Plates

(1167-D) Competition assay using Fluorescence Polarization to determine the Residence Times for Calcitonin and AMYR agonist, AM833

(1169-B) Measuring protein ligand binding with an endogenous HiBiT CETSA test system

(1171-D) High-Throughput Automation of Plasmid DNA Extraction Enhances Efficiency and Reliability

(1179-D) Comparison of Transient Gene Delivery Methods in Human iPSC-derived Neurons and Glia

(1182-C) Binding and Functional Characterization of Anti-HER2 Antibodies Using Advanced Flow Cytometry and BLI Label-Free Detection

(1183-D) Quantifying in vitro complement-dependent cytotoxicity (CDC) using advanced flow cytometry

(1185-B) Generation and characterisation of a panel of human iPSC-derived neurons and microglia carrying early and late onset relevant mutations for Alzheimer’s disease

(1191-D) A cell- and organelle-targetable thallium indicator for fluorescence-based ion channel assays

(1193-B) A Comparative Analysis of Compound Clustering and HIT Prediction Variability in Cell Painting Assays Using Supervised and Unsupervised Deep Learning and CellProfiler Methods.

(1195-D) A genome-scale CROP-Seq screen reveals mediators of T cell signaling

(1196-A) TracerDB: A comprehensive database of validated fluorescent probes to quantify small molecule-protein interaction in vitro and in live cells

(1198-C) A guide for reliable nucleic acid characterization in high-throughput applications

(1199-D) A live cell PRMT5 NanoBRET Target Engagement Assay querying competitive and uncompetitive modes of inhibition

(1202-C) A Platform for Novel Target Discovery - Delivering Complexity & Robustness into Arrayed Immuno-Oncology Screens at AstraZeneca

(1205-B) A walkaway solution for assessing drug effects on patient-derived cancer organoids

(1209-B) Addition of Covalent Warhead and DEL-generated Hit Fragmentation empower Fragment-Based Drug Discovery

(1211-D) Advancing Antibody Discovery with OmniAb: High-Throughput Screening with xPloration™

(1213-B) Advancing Drug Discovery through 3D Cell Models: Unveiling Novel Hits and Mechanisms

(1214-C) Advancing Gene Therapy: Integrating Automated RNA Potency Assays for Precise AAV Vector Characterization

(1215-D) Affinity Selection-Mass Spectrometry HTS Applied to Challenging Drug Targets.

(1216-A) An automated plasmid purification protocol – avoiding ancillary equipment and reducing manual intervention.

(1219-D) Applications of Open Port Sampling Mass Spectrometry to Increase Throughput

(1220-A) Applying RT-qPCR for HTS of Transcription Factors

(1222-C) At-scale Enablement of a Human Bronchial Epithelial (huBEC) Cell Air Liquid Interface (ALI) Model for Respiratory Antiviral Program Support with Potential for Improved Human Physiological Relevance

(1223-D) Automated and Open-source Biochemical Assay Method Development Using an Inexpensive Robotic Liquid Handler

(1237-B) Bioluminescent cell-based reporter identifies atypical activator of human Sonic Hedgehog Autoprocessing

(1239-D) Biophysics in Kinase Drug Discovery: from Fragment-based Screening to PROTAC Ternary Complex Characterization

(1242-C) Cell and tissue-based in vitro pulmonary fibrosis assays for identification of compounds with potential anti-fibrotic activity

(1244-A) Ceramide scoring for Cardiovascular Disease risk prediction using Agilent Rapidfire SPE-MS/MS

(1245-B) CETSA®: Accelerating Primary Screening of P53 through Rapid High-Throughput Target Engagement Technology

(1246-C) Chromatography Free Measurements Enabling Rapid Quantitation of Synthetic Cannabinoids in Urine

(1247-D) AptaFluor® SAH: A Homogenous, Universal Assay for Histone, RNA, and DNA Methyltransferases. Case Study for PRMT5, MLL4, METTL3/14, and NSP14

(1251-D) Corning Matrigel matrix Supplemented Media for Pancreatic Cancer Organoid Assays

(1252-A) CRISPR platform for Target Identification and Validation at Evotec

(1255-D) Deep characterization of binding kinetics for 210 kinase inhibitors against 80+ kinases

(1257-B) DELs to NanoBRET Probes: Enabling Cell-Active Target Engagement

(1258-C) Detection and Quantification of Cellular cGAMP using Homogenous HTS Formatted Bioluminescent Assay

(1259-D) Determination of Cell Viability using High-Dimensional Morphology Analysis

(1267-D) Development of a HiBit peptide-based nanoBRET ligand binding assay for galanin receptor 1 in the live cell

(1268-A) Development of a High Throughput Cell Based Activity Screen to Identify Inhibitors of a Complex First in Class Redox Enzyme using Acoustic Ejection Mass Spectrometry (AEMS)

(1269-B) Development of a high-throughput assay using exhausted T cells for screening immune checkpoint modulators

(1270-C) Development of an Automated Gyrolab® Generic Toxicokinetic Method for the Quantification of Human IgG-based Molecules

(1272-A) Differential binding of ∆9-tetrahydrocannabinol derivatives to type 1 cannabinoid receptors (CB1)

(1278-C) Enhancing Molecular Lab Efficiency Through Comprehensive Automation of Bioanalytical Workflows

(1282-C) Evaluation of Capillary Mediated Vitrification as an Alternative to Traditional Cold Temperature Storage for Kinase Assay Reagents

(1283-D) Facilitating combination therapy studies on-a-chip with patient-derived 3D tumour models

(1284-A) Fast Post-thaw Recovery of Cryopreserved Cells for Use in Bioassays

(1285-B) First-in-class Selectivity System for Quantitative Kinase Inhibitor Profiling in Live Cells against 192 Kinases

(1288-A) Fluorescence-based drug repurposing screen of the potassium channel, KV3.1 with V434L mutation.

(1289-B) From Paper to Assay: a Case-Study on Adapting, Developing, and Troubleshooting an Enzymatic Assay for High-Throughput Screening.

(1293-B) Functional Assays at the Single Cell Level: ​Advantages and Applications for NK Killing Assays

(1294-C) Functional Characterization of Healthy and Alzheimer’s Disease-related 3D Neurospheres Formed Using Human iPSC-derived Glutamatergic Neurons, GABAergic neurons, and Astrocytes.

(1295-D) Functional Phenotypic Excitation of Human iPSC-derived Spinal Motor Neurons Cultures from Amyotrophic Lateral Sclerosis Patients

(1296-A) Gene-Edited Induced Pluripotent Stem Cell-Derived Microglia as a Platform for Neurodegenerative Research

(1299-D) Glass-bottom Nanowell-in-microwell Imaging Plates

(1301-B) Harnessing the power of qHTS and Machine Learning for the discovery SARS-CoV-2 Papain-Like protease inhibitors

(1302-C) High content image analysis of human cortical adherent organoids: 3D MICro-brains

(1303-D) High Throughput Analytics: Automation of HPV Yeast Sample Preparation for Intracellular HPV Protein Flow Cytometry

(1304-A) High throughput production and assessment of uniform 3D cultures using the Corning® Elplasia® 12K Open Well Plate.

(1306-C) High-content immunofluorescence screen identifies ingenol-3-angelate to increase B7-H3-CAR T antigen expression on lung metastatic osteosarcoma cells

(1307-D) High-throughput Affinity Selection Mass Spectrometry Using a Novel Two Dimensional RapidFire TOF Platform

(1308-A) High-Throughput Biologics Discovery, Production, and Characterization Using Automated Workstations

(1309-B) High-Throughput Optimization of Paper-Based Cell-Free Biosensors

(1310-C) High-throughput pathway screening and target deconvolution of novel oncogenic YAP/TAZ signaling pathway inhibitors

(1311-D) High-throughput Sample Preparation Enabling Rapid Protein Quantitation via Targeted Mass Spectrometry

(1312-A) High-throughput screening using a novel HER2-positive brain metastatic breast cancer model identifies the pan-ErbB inhibitor poziotinib

(1314-C) Homogeneous Antibody-Binding Assay Using High-Throughput Microscopy

(1315-D) Homogeneous Luminescent Immunoassays for Proliferation and Senescence

(1316-A) Host heparan sulfate promotes ACE2 super-cluster assembly and enhances SARS-CoV-2-associated syncytium formation

(1317-B) Identification of broad-spectrum inhibitors against Bunyaviral endonucleases

(1318-C) Identification of compounds targeting KRAS and SHP2 from the National Cancer Institute diversity compound library with protein conformational array

(1319-D) Identifying potential adverse health effects of chemicals by screening on a panel of safety-related biological targets

(1322-C) Innovative approaches to cancer research: High-throughput screening combined with live-cell imaging for drug response analysis

(1323-D) Insights about Affinity Selection Mass Spectrometry gleaned from computational simulation

(1324-A) Insights into the dynamics of PCSK9/LDLR interaction: effect of gain-of-function mutations and pH-dependent affinity

(1325-B) Insights into the Molecular Mode of Action of Compounds Targeting Nucleases and Helicases Utilizing switchSENSE

(1326-C) Integrating Automated High-Throughput Scratch Assay and Cell Painting for Comprehensive Analysis of Cell Migration and Wound Healing

(1328-A) Introduction of Zeon Original Coating COP Microplates for Cell Imaging

(1329-B) LabChip GX II Touch system for gene therapy applications: High-throughput AAV empty/full characterization

(1332-A) Large Scale Screening of Drug Candidates from Multiple Modalities using Biophysical Technologies in Early-Stage Drug Discovery

(1333-B) Large-scale Characterization of Drug Candidates Against Transmembrane Receptors using HT-SPR

(1337-B) Lumit™ Cytokine Immunoassay Automation for High-Throughput Screening

(1339-D) MCSR-HTSC at OSU: an academic high throughput screening core facility for early cancer drug discovery

(1340-A) Method Updates in the Measurement of Heterocyclic Aromatic Amines in Human Urine using Hamilton Starlet Automated Liquid Handling Platform and LC-ESI-MS/MS

(1344-A) Microglia integrated 3D neural spheroids for disease modeling and therapeutic development

(1345-B) Miniaturization of fluorescent kinetic assay for optimal conditions: maximizing fluorescence while minimizing volume.

(1346-C) Modeling rare genetic diseases for drug discovery with C. elegans quantitative high throughput screening (qHTS)

(1349-B) Natural Product Compound Fractionization of the Lion’s Mane Mushroom and HTS Analysis of its Effects on Multiple Models of Neuronal Disorders

(1351-D) Neurotoxicity and Drug Screening Assay Characterization in Healthy and Progranulin R493X HZ KO Human iPSC-derived Induced Excitatory Neurons

(1352-A) Nuisance compound behavior in cellular assays: nonspecific membrane bilayer perturbations by ivermectin underlie SARS-CoV-2 in vitro activity

(1354-C) Optimization of high-throughput human glutathione peroxidase GPx1 and GPx4 assays for the discovery of small molecule inhibitors

(1356-A) Phenotypic Screening using hPSC Neurons on Multi-Electrode Array (MEA) with Novel Analysis Methodology combined with Genedata Screener

(1361-B) Quantitative high throughput screening methods for Rift Valley Fever Virus

(1362-C) Quantitative high-throughput screening-enabled drug repurposing identifies small molecule inhibitors of Chikungunya nsP2 protease

(1364-A) Rapid Cellular Functional Activity Profiling of Multi-Receptor Targeted Anti-Obesity Therapies

(1365-B) Reactive oxygen species detection using a luminescent cell-based assay

(1366-C) Real Time Cellular Thermal Shift Assay (RT-CETSA) Instrument Development

(1370-C) Robotics for Revolutionizing T Cell Engager Drug Discovery

(1372-A) Scalable patient derived 3d colorectal cancer organoids in high throughput applications

(1374-C) Screening for Success – Enhancing Hit Confidence from Affinity Selection Mass Spectrometry (ASMS) Screens

(1375-D) Single molecule real-time analysis of dynamic nucleic acid interactions

(1376-A) Structure-guided monitoring of the human opioid receptor family using BRET assays

(1377-B) Sustainable Vitamin A; Automating a Viability Assay to Increase Sample Processing Capacity and Gain More Insights

(1379-D) Targeting NETosis in Autoimmune Diseases

(1380-A) Ternary complex assays: Optimizing AlphaLISA Toolbox reagents for targeted protein degradation applications

(1381-B) The Best Of Both Worlds - Tailored Analysis Of Affinity Selection MS Data With A Generic Automation Engine

(1383-D) The DISCovery Centre (UK): Expanding the horizon of new automated DMTA assay possibilities.

(1384-A) The search for small molecule, non-nucleoside inhibitors of SARS-CoV-2 RNA-Dependent RNA Polymerase

(1390-C) Uncovering Key Regulators of the Ewing Sarcoma EWSR1 Gene using a Genome-Wide RNAi Screen.

(1391-D) Using computational simulation to distill best practices for applying the Morrison equation to biochemical pharmacology data

(1392-A) Using DNA Encoded Library Selections and Hit Calling to Predict Target Tractability and Accelerate Portfolio Activities.

(1393-B) Using Mass Spectrometry detection to mitigate fluorescence interference and potency detection limits in a plate-based kinase assay panel.

(1397-B) Wastewater surveillance of infectious disease using an integrated handheld device

(1398-C) WaveFront Panoptic Kinetic Plate Imaging Platform for Early Phase Drug Discovery at Vanderbilt High Throughput Screening Center

(1399-D) Workflow Development for Wastewater-Based-Epidemiology via Low-Cost Metagenomic Sequencing of Antimicrobial Resistance in Sub-Saharan Africa

(1402-C) Drastically Accelerated Directed Differentiation of Human Pluripotent Stem Cells into Motor Neurons for Disease Modeling and Screening Applications

(1403-D) Interrogating RIG-I and MDA5 with the Transcreener® ADP2 Assay

(1404-A) Leveraging the Molecular Devices SpectraMax® i3x and the Transcreener® ADP2 Assay for Discovery of POLQ Helicase Inhibitors

(1406-C) Scalable and Efficient Generation of iPSC-derived Human Sensory Neurons for CIPN and Pain Research