(1375-D) Single molecule real-time analysis of dynamic nucleic acid interactions
Tuesday, February 6, 2024
2:00 PM – 3:00 PM EST
Location: Exhibit Halls AB
Abstract: Despite the enormous technological advances made in genomics over recent years, the latest tools still fall short in their ability to fully capture the dynamic molecular interactions within cells that are essential for understanding the underlying biology of health and disease. Based on established force spectroscopy technology, MAGNA is a novel platform for analyzing the complex interactions between different biomolecules, with potential application across a broad range of areas within life science research. We have already generated rich data sets revealing how nucleic acids, DNA- & RNA binding proteins, antibodies, and small-molecule compounds bind to their targets. As an example of this, we demonstrate how MAGNA can be used to explore the binding events between nucleic acids (in this case RNA), and ligands such as proteins and small molecule compounds, to inform the development of RNA- targeted therapeutics.