(1322-C) Innovative approaches to cancer research: High-throughput screening combined with live-cell imaging for drug response analysis
Tuesday, February 6, 2024
12:00 PM – 1:00 PM EST
Location: Exhibit Halls AB
Abstract: The continuous evolution of toxicology and cytotoxicity research demands innovative methodologies that not only provide high-throughput capabilities but also offer real-time insights into dynamic cellular responses. The Omni Pro 12, a cutting-edge automated live-cell imaging device, stands as a pivotal tool in advancing laboratory automation for high-throughput experimentation. The Omni Pro 12 is a high-throughput live-cell imaging screening platform designed for continuous imaging inside the incubator and accommodates up to 12 microwell plates at a time. This study focuses on leveraging the synergy between high-throughput screening and live-cell imaging to elucidate the drug-dependent cellular responses of a prominent chemotherapeutic agent, Docetaxel, in a few human cancer cell lines.
Utilizing the Omni Pro 12, we systematically dosed well-characterized human cancer cell lines with varying concentrations of Docetaxel, assessing, among others, cancer cell proliferation and cytotoxicity in parallel. The cells exhibited a distinct and dose-dependent response for all assays, underlining the versatility of the Omni Pro 12 in handling diverse experimental setups. The combination of high-throughput and live-cell imaging provided a nuanced understanding of the temporal aspects of Docetaxel-induced cytotoxicity, allowing for the identification of critical morphological alterations as well as a comprehensive analysis of the drug’s impact across various cellular behaviors.
Our findings not only underscore the Omni Pro 12’s utility in dissecting the multifaceted responses of cancer cells but also highlight the importance of comprehensive, parallel experimentation for obtaining accurate and meaningful results in drug evaluation studies using simple live-cell imaging assays. The Omni Pro 12 emerges as an ideal device for seamlessly combining high throughput with precision, enabling researchers to conduct complex experiments efficiently.