(1161-B) Fast Kinetic Imaging and Analysis of Intracellular Dynamics in Human iPSC- derived Neurons
Monday, February 5, 2024
2:00 PM – 3:00 PM EST
Location: Exhibit Halls AB
Abstract: The study of intracellular dynamic processes is of fundamental importance for unraveling the mechanisms of a broad spectrum of diseases and to develop effective drugs and therapies. Particularly in the field of neuroscience and neurodegenerative diseases, two intracellular events are of critical importance: mitochondrial movements and calcium signaling in neurons. Here we apply fast kinetic imaging using our high-content imaging and analysis systems to visualize and evaluate these dynamic events in human iPSC-derived neurons with high temporal resolution. By capturing and analyzing kinetic image sequences, we gain valuable insights into the dynamics of mitochondria in live cells to shed light on their role in neuronal health and dysfunction. Furthermore, our approach enables the precise assessment of calcium flux in single neurons, crucial for understanding the fundamental processes of neuronal communication and potential disruptions associated with neurodegenerative disease or neurotoxic insults. Overall, fast kinetic imaging coupled with high-content screening represents a comprehensive automated approach to investigate intracellular dynamics in neurons in real time.