(1057-B) In vitro cytotoxicity and genotoxicity of chalk dust particles generated in South African class rooms
Monday, February 5, 2024
2:00 PM – 3:00 PM EST
Location: Exhibit Halls AB
Abstract: The toxicity of chalk particles depends on the chemical composition, size, number, and shape of the particles. Smaller particles with particulate matter 2.5, in particular, are of concern because they can remain suspended in the air for long periods and travel distances from the point of release. The longer the particles are suspended, the higher the chances of exposure. Owing to their size, smaller particles can deposit deeper into the alveoli region relative to larger particles that deposit in the head and tracheobronchial region. Furthermore, smaller particles cannot easily be cleared by macrophages and phagocytes in the lungs, hence they are retained for longer periods. The aim of the study is to determine the in vitro (alveolar macrophages) cytotoxicity and genotoxicity of chalk dust particles generated in classrooms using a variety of chalks and the potential associated health risks in South Africa. The cytotoxicity and genotoxicity of chalk particles determined by using xCELLigence real time analyser and Comet assay respectively. The results show that chalk particles with PM 2.5 shows cytotoxicity and can induce DNA damage genotoxic effects. The results of this study should serve as a reference for improving indoor air quality and protecting teachers and students from harmful dust particles in classroom