(1087-D) Vascular inflammation modulates Trans-Endothelial Electrical Resistance and immune cell migration in a scalable organ-on-a-chip platform
Tuesday, February 6, 2024
2:00 PM – 3:00 PM EST
Location: Exhibit Halls AB
Abstract: The vasculature system plays a critical role in the body inflammation processes. Vascular inflammatory mechanisms are characterized by disruption of blood vessel wall permeability together with increased immune cell recruitment and migration. There is a critical need to develop models that fully recapitulate changes in vascular barrier permeability in response to inflammatory conditions. To this extent, we demonstrate a platform for inducing inflammatory reaction in HUVEC based microfluidic barrier models combined with continuous Trans Epithelial Electrical Measurements and coculture with Human peripheral Blood mononuclear cells. We found that the endothelial barrier changes differently depending on the inflammatory cytokine or immune cells added leading to changes in ICAM expression and endothelial morphology. We propose our platform as an essential tool for modeling endothelial inflammation in combination with immune cell interaction that can be used to screen for different targets and drugs to treat chronic vascular inflammation.