(1125-B) The Multichannel Verification System (Artel MVS®) by Advanced Instruments Delivers Equivalent Results to the Fluorescence Test Method Utilized by Beckman Coulter Life Sciences to Evaluate the Echo Acoustic Liquid Handler Systems

Abstract: Beckman Coulter Life Sciences Echo acoustic liquid handlers are automated liquid handlers (ALHs) that use acoustic technology to provide contact-free transfer of liquids in increments of 2.5 nL or 25 nL depending on the model/series. The Echo is compatible with common solvents for biopharmaceutical applications including dimethyl sulfoxide (DMSO) and a variety of aqueous-based solutions. Beckman Coulter Life Sciences currently uses a fluorescence method to evaluate the accuracy and precision of systems. Beckman Coulter Life Science customers have asked for an in-house method to validate the performance of the Echo to save time and enable on-demand volume verification. Artel by Advanced Instruments provides a complete system, the Multichannel Verification System (Artel MVS®), that can be used for liquid handler evaluation at a customer site without the need to generate standard curves. The Artel MVS is also compliant with ISO 23783-2: Measurement procedures for the determination of volumetric performance. This study was designed to evaluate whether the Artel MVS and Beckman Coulter Life Sciences fluorescence test methods provide equivalent volume verification results at 25 nL and 250 nL on Series-525 and Series-655 for select aqueous and DMSO solutions. This work has demonstrated the equivalence of the Artel MVS test method compared to the fluorescence test method employed by Beckman Coulter Life Sciences, for the selected plate types described.