(1398-C) WaveFront Panoptic Kinetic Plate Imaging Platform for Early Phase Drug Discovery at Vanderbilt High Throughput Screening Center
Tuesday, February 6, 2024
12:00 PM – 1:00 PM EST
Location: Exhibit Halls AB
Abstract: High-throughput Screening (HTS) in early phase drug discovery requires the efficient screening of compound libraries to identify potential hits that interact effectively with therapeutic targets such as ion channels, G protein-coupled receptors (GPCRs), and enzymes. To meet this need, the WaveFront Panoptic is a highly advanced kinetic whole plate imager equipped with built-in 96/384-channel liquid handling robotics and up to nine plate holder nests. This automated system is capable of measuring fluorescence and/or luminescence, simultaneously from all wells of a microplate. When the Panoptic is integrated with a BioTek plate washer, Thermo MultiDrop Combi, Thermo Cytomat, and Waveguide data acquisition software, it serves as an efficient and versatile automation platform for Vanderbilt's HTS and early phase drug discovery efforts. Over the past 10 years, the utilization of Panoptic in the Vanderbilt HTS Center, has contributed to more than 50 publications and has supported successful research projects and proposals involving the discovery and characterization of small molecule modulators of ion channels (e.g., Kv, IRKs, SLACK, VRAC, SLO3, etc.), ion transporters (such as KCC2) and GPCRs (e.g., 5-HTRs, mAchRs, mGluRs), the development of novel bioluminescent assay reporters (e.g., CalfluxCTN), and the identification of new activator chemotypes for enzymes (such as NAPE-PLD). With two automated Panoptic systems and other state-of-the-art instruments, the Vanderbilt HTS Center offers comprehensive screening-based services for all stages of the drug discovery process. The Center provides instrument training, compound management, assay development, assistance with data analysis, and post-screen hit validation (dose dependence), among other services. These resources greatly facilitate the identification and optimization of chemical tools, leading to the discovery of potential lead compounds for the development of novel therapeutics.