(1304-A) High throughput production and assessment of uniform 3D cultures using the Corning® Elplasia® 12K Open Well Plate.
Monday, February 5, 2024
12:00 PM – 1:00 PM EST
Location: Exhibit Halls AB
Abstract: Three-dimensional (3D) multicellular cultures are advantageous to traditional two-dimensional (2D) monolayer cultures because the cells more closely resemble the tissue source of origin. 3D cell cultures have increased cell-to-cell interactions as well as gradients of soluble factors such as nutrients, oxygen, and metabolites that are more similar to solid tissues. The Corning® Elplasia® 12K Open Well Plate addresses the need for high throughput production of up to 12,000 scaffold-free, high quality, 3D cultures that are uniform in size and shape. The Corning Elplasia 12K plate design incorporates the Elplasia 12K flask microcavity substrate in a standard ANSI/SLAS. The microplate footprint is equipped with a removable lid to allow users easy access to the cultures and compatibility with automated imagers and equipment. Here, we use human induced pluripotent stem cells (hiPSCs) to demonstrate the bulk formation of homogenous iPSC derived embryoid bodies (EBs) in the Corning Elplasia 12K plate.